Published January 1987
by Springer .
Written in English
|The Physical Object|
|Number of Pages||489|
Nicotinic Acetylcholine Receptor Structure and Function in the Efferent Auditory System LAWRENCE R. LUSTIG* Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, California ABSTRACT This article reviews and presents new data regarding the nicotinic acetylcholine receptor subunits 9 and Nicotinic acetylcholine receptors (nAChRs) belong to the "Cys-loop" superfamily of ligand-gated ion channels that includes GABAA, glycine, and serotonin (5-HT3) receptors. There are 16 homologous mammalian nAChR subunits encoded by a multigene family. These subunits combine to Cited by: Insect pest control has continuously evolved from inorganics to botanicals, to chlo rinated hydrocarbons, to organophosphorus compounds and methylcarbamates, then synthetic pyrethroids and most recently synthetic nicotinoids as the major classes. These insecticides allowed high standards of crop protection at minimal cost. A limitation in each new class of compounds is the selection of. J.-P. Changeux, Y. Paas, in Encyclopedia of Neuroscience, The nicotinic acetylcholine receptor is a transmembrane allosteric protein that mediates transduction of chemoelectric signals throughout the nervous system by opening an intrinsic ionic channel. This rapid pore opening enables flow of Na +, K +, and, in several instances, Ca 2+ ions across the cell membrane.
Structure and function of the nicotinic acetylcholine receptor. The nicotinic acetylcholine receptor (NAR) is the most widely studied receptor ion channel. This is due to a very practical reason – availability. The receptor can be isolated in high yield from electric eel or electric ray, both of which use strong electric discharges to. Nicotinic receptor structure and subtypes. Nicotinic acetylcholine receptors are ligand-gated cation channels that are widely distributed throughout the nervous system and body (Papke, ), but this section will focus on neuronal nAChRs (Dani and Bertrand, ). 1. Introduction. The nicotinic acetylcholine receptors (nAChRs) are of a family of ligands gated ion channels that are expressed in the cell membrane of all mammalian cells, including cancer cells .In the nervous system nAChRs have high permeability to calcium, modulated by the extracellular calcium concentrations, phosphorylated by calcium-dependent serine/threonine kinases to regulate the. nicotinic receptor subunit structure and diversity and receptor specialization The significance of nAChRs to modulate biological function rests in their ability to translate the binding of an endogenous agonist, such as ACh, to receptor motion that will gate the channel to .
Abstract. Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels and can be divided into two groups: muscle receptors, which are found at the skeletal neuromuscular junction where they mediate neuromuscular transmission, and neuronal receptors, which are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. Cited by: Monoclonal Antibodies as Probes of Acetylcholine Receptor Function.- Antigenic Specificity of Monoclonal Antibodies Against Torpedo 93 and Human Acetylcholine Receptor, and Use of these Anti-bodies to Investigate Myasthenia gravis.- Tertiary Structure of the Nicotinic Acetylcholine Receptor Probed by Photolabeling and Protein Chemistry ACh acts on two classes of receptors, nicotinic and muscarinic, each demonstrating unique functional, pharmacologic, and molecular properties. All nicotinic acetylcholine receptors are ligand‐gated ion channels and are pentamers composed of homologous protein subunits, each subunit spanning the plasma membrane four times (Sargent, ). Molecular Biology of Nicotinic Acetylcholine Receptors from Chicken Muscle and Brain Eric A. Barnard, David M. W. Beeson, Victor B. Cockcroft, Mark G Darlison, Andrew A. Hicks, F. Anthony Lai et al. Pages