|Statement||Falk Symposium 45 ; edited by G. Paumgartner, A. Stiehl, W. Gerok.|
|Contributions||Paumgartner, G., Stiehl, A. 1941-, Gerok, W. 1926-, Bile Acid Meeting (9th : 1986 : Basel, Switzerland)|
|LC Classifications||RC850 .F35 1986|
|The Physical Object|
|Pagination||xxiv, 384 p. :|
|Number of Pages||384|
|LC Control Number||87017064|
Bile acids are increasingly being seen as extremely important carcinogenic agents in cancers of the bile duct, liver, colon, rectum, and oesophagus. They are essential agents involved in lipid digestion and absorption in mammals, however, they also play wide-ranging roles in a variety of disease states ranging from diabetes to : Hardcover. Bile acid synthesis is tightly regulated by complex mechanisms to maintain low levels of bile acids in the liver. In the liver, FXR inhibits CYP7A1 gene transcription indirectly via inducing the negative nuclear receptor small heterodimer partner (SHP). In the intestine, FXR induces fibroblast growth factor 19 (FGF19), which activates liver FGF Cited by: 1. Activation or modulation of bile acid receptors, such as the farnesoid X receptor and TGR5, and transporters, such as the ileal apical sodium‐dependent bile acid transporter, appear to affect both insulin sensitivity and NAFLD/NASH pathogenesis at multiple levels, and these approaches hold promise as novel by: This book focusses on the latest results related to the field of bile acids as signaling molecules and describes how these receptors have become a major pharmacological target. It covers all major areas of research in this field, from genetics, chemistry, in silico modeling, molecular biology to clinical applications, offering a cross-country view.
Bile acids are increasingly being seen as extremely important carcinogenic agents in cancers of the bile duct, liver, colon, rectum, and oesophagus. They are essential agents involved in lipid digestion and absorption in mammals, however, they also play wide-ranging roles in a variety of disease states ranging from diabetes to cancer. They have evolved exquisite mechanisms for controlling. SK Bile acids are a class of molecules that are involved in a variety of biological processes, such as digestion and basic liver functions, as well as with adaptation to liver disease. Bile acid therapy was essentially first systematically used for certain types of gallstones; in addition, bile extracts have had homeopathic historic and regional by: 1. The most abundant bile acids in human bile are chenodeoxycholic acid (45%) and cholic acid (31%).These are referred to as the primary bile the primary bile acids are secreted into the canalicular lumen they are conjugated via an amide bond at the terminal carboxyl group with either of the amino acids glycine or taurine. Ichimiya, H, Egestad, B, Nazer, H, et al. Bile acids and bile alcohols in a child with hepatic 3β-hydroxy-Δ5-Csteroid dehydrogenase deficiency: effects of chenodeoxycholic acid treatment. J Cited by: 1.
Why the Liver is Important. The liver performs more than vital functions in the body, according to the University of Virginia Health System. The most important function is maintaining a healthy metabolism. The liver also regulates chemical levels in the blood, excretes bile to help breakdown fats and processes all of the blood in your body. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, . The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver. The gut-liver circulation of bile acids plays an important role in controlling the metabolism of lipids in the liver and intestine systems (Schneider, Albers, & Trautwein, ), where FXR is a.